GRL0617
Cat. No.：YN250263
CAS No. ：1093070-16-6
| 产品名称: | GRL0617 |
| CAS No.: | 1093070-16-6 |
| Chemical Name: | 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-benzamide |
| Synonyms: | GRL0617;GRL 0617 |
| 分子量: | 304.39 |
| 分子式: | C₂₀H₂₀N₂O |
| SMILES: | O=C(N[C@@H](C1=C2C=CC=CC2=CC=C1)C)C3=CC(N)=CC=C3C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GRL0617 是一种强效、选择性和竞争性的SARS-CoV PLpro/deubiquitinase的非共价抑制剂，其IC50值为 0.6 μM，Ki值为 0.49 μM. |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ratia, K., Pegan, S., Takayama, J., et al.A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replicationProc. Natl. Acad. Sci. USA105(42),16119-16124(2008)
Shin, D., Mukherjee, R., Grewe, D., et al.Papain-like protease regulates SARS-CoV-2 viral spread and innate immunityNature587(7835),657-662(2020)
