Reldesemtiv
Cat. No.：YN480411
CAS No. ：1345410-31-2
规格
价格(RMB)
库存
| 产品名称: | Reldesemtiv |
| CAS No.: | 1345410-31-2 |
| Chemical Name: | 1-[2-({[trans-3-Fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5yl]-1H-pyrrole-3-carboxamide; CK 2127107; 1-[2-[[[trans-3-Fluoro-1-(3-fluoro-2-pyridinyl)cyclobutyl]methyl]amino]-5-pyrimidinyl]-1H-pyrrole-3-carboxamide; |
| Synonyms: | CK-2127107 |
| 分子量: | 384.38 |
| 分子式: | C₁₉H₁₈F₂N₆O |
| SMILES: | O=C(C1=CN(C2=CN=C(NC[C@]3(C4=NC=CC=C4F)C[C@H](F)C3)N=C2)C=C1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Reldesemtiv (CK-2127107) 是一种选择性的，口服活性的下一代快速骨骼肌肌钙蛋白 (fast skeletal muscle troponin) 激活剂 (FSTA)。Reldesemtiv 选择性激活快速骨骼肌原纤维，EC50为3.4μM。Reldesemtiv 可提高心力衰竭模型的运动表现。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Calder, A. N., et al.: J. Med. Chem., 59, 10067-10083 (2016)
Hwee, D. T., et al.: J. Pharmacol. Exp. Ther., 353, 159-168 (2015)
