Imipramine hydrochloride
Cat. No.：YN380203
| 产品名称: | Imipramine hydrochloride |
| CAS No.: | 113-52-0 |
| Chemical Name: | 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, monohydrochloride |
| Synonyms: | 盐酸丙咪嗪 |
| 分子量: | 316.87 |
| 分子式: | C₁₉H₂₅ClN₂ |
| SMILES: | CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Imipramine hydrochloride 抑制血清素转运蛋白(serotonin)，体内试验的IC50值为32 nM。Imipramine hydrochloride 可阻止胰酶的易位，抑制 MV 和外泌体的分泌。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Spencer, P.S.Review of the pharmacology of existing antidepressantsBr. J. Clin. Pharmacol.4(Suppl 2),57S-68S(1977)
Yates, C.M., Todrick, A., and Tait, A.C.Effect of imipramine and some analogues on the uptake of 5-hydroxytryptamine by human blood platelets in vitroJ. Pharm. Pharmacol.16,460-463(1964)
Glowinski, J., and Axelrod, J.Inhibition of uptake of tritiated-noradrenaline in the intact rat brain by imipramine and structurally related compoundsNature204,1318-1319(1964)
Cusack, B., Nelson, A., and Richelson, E.Binding of antidepressants to human brain receptors: Focus on newer generation compoundsPsychopharmacology (Berl.)114(4),559-565(1994)
Carpinteiro, A., Edwards, M.J., Hoffmann, M., et al.Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cellsCell Rep. Med.1(8),100142(2020)
