GC7 Sulfate
Cat. No.：YN290083
CAS No. ：150417-90-6
规格
价格(RMB)
库存
| 产品名称: | GC7 Sulfate |
| CAS No.: | 150417-90-6 |
| Chemical Name: | (7-aminoheptyl)-guanidine, monosulfate |
| Synonyms: | N1-guanyl-1,7-diaminoheptane Sulfate |
| 分子量: | 270.35 |
| 分子式: | C₈H₂₂N₄O₄S |
| SMILES: | NC(NCCCCCCCN)=N.O=S(O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GC7 Sulfate 是一种脱氧嘌呤合成酶 (DHPS) 抑制剂。 |
| IC50和靶点: | |
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Jakus, J., Wolff, E.C., Park, M.H., et al.Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyaminesJ. Biol. Chem.268(18),13151-13159(1993)
Lou, B., Fan, J., Wang, K., et al.N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cellsExp. Cell Res.319(17),2708-2717(2013)
Jasiulionis, M.G., Luchessi, A.D., Moreira, A.G., et al.Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growthCell Biochem. Funct.25(1),109-114(2007)
