E3330
Cat. No.：YN290455
CAS No. ：136164-66-4
规格
价格(RMB)
库存
| 产品名称: | E3330 |
| CAS No.: | 136164-66-4 |
| Chemical Name: | (2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid |
| Synonyms: | APX-3330 |
| 分子量: | 378.46 |
| 分子式: | C₂₁H₃₀O₆ |
| SMILES: | CCCCCCCCC/C(C(O)=O)=C\C1=C(C)C(C(OC)=C(OC)C1=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | E3330 (APX-3330) 是一种直接，口服有效的，选择性的 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂，可抑制NF-κB DNA 结合活性。E3330 (APX-3330) 阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活。E3330 (APX-3330) 显示出抗癌特性，可以抑制癌细胞的生长和迁移。 |
| IC50和靶点: | |
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Luo, M., Delaplane, S., Jiang, A., et al.Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: Small-molecule inhibition of the redox function of Ape1Antioxid. Redox Signal.10(11),1853-1867(2008)
Fishel, M.L., Jiang, Y., Rajeshkumar, N.V., et al.Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growthMol. Cancer Ther.10(9),1698-1708(2011)
