Quarfloxin
Cat. No.：YN290312
CAS No. ：865311-47-3
| 产品名称: | Quarfloxin |
| CAS No.: | 865311-47-3 |
| Chemical Name: | 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide |
| Synonyms: | CX-3543 |
| 分子量: | 604.67 |
| 分子式: | C₃₅H₃₃FN₆O₃ |
| SMILES: | O=C(C1=CN2C3=C(C(N4CC(C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Quarfloxin (CX-3543) 是一种具有抗肿瘤活性的氟喹诺酮类衍生物，其靶向抑制RNA pol I的活性，在神经母细胞瘤中的IC50值在纳摩尔级别。Quarfloxin 干扰核糖体DNA中核蛋白与G-四重DNA结构的相互作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Drygin, D., Siddiqui-Jain, A., O'Brien, S., et al.Anticancer activity of CX-3543: A direct inhibitor of rRNA biogenesisCancer Res.69(19),7653-7661(2009)
