Rubitecan
Cat. No.：YN290291
CAS No. ：91421-42-0
| 产品名称: | Rubitecan |
| CAS No.: | 91421-42-0 |
| Chemical Name: | (4S)-ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Synonyms: | RFS 2000; 9-Nitrocamptothecin |
| 分子量: | 393.35 |
| 分子式: | C₂₀H₁₅N₃O₆ |
| SMILES: | O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C([N+]([O-])=O)C=CC=C5N=C4C3=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rubitecan (RFS 2000)，喜树碱衍生物，是一种口服活性拓扑异构酶 I抑制剂，具有广泛抗肿瘤活性，诱导蛋白质连接的 DNA 单链断裂，从而阻断分裂细胞中的 DNA 和 RNA 合成。 |
| IC50和靶点: | |
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Rubin, E., Pantazis, P., Bharti, A., et al.Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecinJ. Biol. Chem.269(4),2433-2439(1994)
Hinz, H.R., Harris, N.J., Natelson, E.A., et al.Pharmacokinetics of the in vivo and in vitro conversion of 9-nitro-20(S)-camptothecin to 9-amino-20(S)-camptothecin in humans, dogs, and miceCancer Res.54(12),3096-3100(1994)
Bernacki, R.J., Pera, P., Gambacorta, P., et al.In vitro antitumor activity of 9-nitro-camptothecin as a single agent and in combination with other antitumor drugsAnn. N. Y. Acad. Sci.922,293-297(2000)
Pantazis, P., Mendoza, J.T., Early, J.A., et al.9-Nitro-camptothecin delays growth of U-937 leukemia tumors in nude mice and is cytotoxic or cytostatic for human myelomonocytic leukemia lines in vitroEur. J. Haematol.50(2),81-89(1993)
