Doxercalciferol
Cat. No.：YN470033
CAS No. ：54573-75-0
规格
价格(RMB)
库存
| 产品名称: | Doxercalciferol |
| CAS No.: | 54573-75-0 |
| Chemical Name: | 4-methylene-5Z-[2E-[(1R,3aS)-octahydro-7aR-methyl-1R-[1R,4,5-trimethyl-2E-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3S-cyclohexanediol |
| Synonyms: | 度骨化醇; 1.alpha.-Hydroxyvitamin D2 |
| 分子量: | 412.65 |
| 分子式: | C₂₈H₄₄O₂ |
| SMILES: | C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](/C=C/[C@@H](C(C)C)C)C)CCC/2)[H])O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Doxercalciferol 是维生素 D2 类似物，为维生素 D (Vitamin D) 受体激活剂，能够抵抗肾病的进程。 |
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Upton, R.A., Knutson, J.C., Bishop, C.W., et al.Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormoneNephrol. Dial. Transplant18,750-758(2003)
Frazao, J.M., Chesney, R.W., Coburn, J.W., et al.Intermittent oral 1α-hydroxyvitamin D2 is effective and safe for the suppression of secondary hyperparathyroidism in haemodialysis patientsNephrol. Dial. Transplant13,68-72(1998)
Brown, A.J., Dusso, A.S., and Slatopolsky, E.Vitamin D analogues for secondary hyperparathyroidismNephrol. Dial. Transplant.17(Suppl),10-19(2002)
Ritter, C.S., and Brown, A.J.Direct suppression of Pth gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptorJ. Mol. Endocrinol.46(2),63-66(2011)
Nguyen-Yamamoto, L., Bolivar, I., Strugnell, S.A., et al.Comparison of active vitamin D compounds and a calcimimetic in mineral homeostasisJ. Am. Soc. Nephrol.21,1713-1723(2010)
Zhang, Y., Deb, D.K., Kong, J., et al.Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: Strong synergism with AT1 receptor antagonistAm. J. Physiol. Renal Physiol.297,F791-F801(2009)
van Ginkel, P.R., Yang, W., Marcet, M.M., et al.1α-Hydroxyvitamin D2 inhibits growth of human neuroblastomaJ. Neurooncol.85,255-262(2007)
Attia, S., Eickhoff, J., Wilding, G., et al.Randomized, double-blinded phase II evaluation of docetaxel with or without doxercalciferol in patients with metastatic, androgen-independent prostate cancerClin. Cancer Res.14(8),2437-2443(2008)
