NGI-1
Cat. No.：YN250268
CAS No. ：790702-57-7
| 产品名称: | NGI-1 |
| CAS No.: | 790702-57-7 |
| Chemical Name: | 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-benzamide |
| Synonyms: | ML414 |
| 分子量: | 394.51 |
| 分子式: | C₁₇H₂₂N₄O₃S₂ |
| SMILES: | O=C(NC1=NC=C(C)S1)C2=CC(S(=O)(N(C)C)=O)=CC=C2N3CCCC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NGI-1 (ML414) 是一种有效的寡糖基转移酶 (OST) 抑制剂，直接靶向和阻断 OST 催化亚基 STT3A 和 STT3B 的功能。NGI-1 是一种细胞渗透性抑制剂，可有效降低病毒感染性而不影响细胞活力。 |
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Lopez-Sambrooks, C., Shrimal, S., Khodier, C., et al.Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cellsNat. Chem. Biol.12(12),1023-1030(2016)
Puschnik, A.S., Marceau, C.D., Ooi, Y.S., et al.A small-molecule oligosaccharyltransferase inhibitor with pan-flaviviral activityCell Rep.21(11),3032-3039(2017)
