Pexidartinib
Cat. No.：YN440364
CAS No. ：1029044-16-3
规格
价格(RMB)
库存
| 产品名称: | Pexidartinib |
| CAS No.: | 1029044-16-3 |
| Chemical Name: | N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine |
| Synonyms: | PLX-3397 |
| 分子量: | 417.81 |
| 分子式: | C₂₀H₁₅ClF₃N₅ |
| SMILES: | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pexidartinib (PLX-3397) 是一种有效的，具有口服活性的、选择性ATP-竞争性的集落刺激因子 1(CSF1R 或 M-CSFR)和c-Kit抑制剂，IC50值分别为 20 和 10 nM。Pexidartinib (PLX-3397) 对 c-Kit 和 CSF1R 的选择性是对其他相关激酶的 10-100 倍，例如 FLT3，KDR (VEGFR2)，LCK，FLT1 (VEGFR1) 和 NTRK3 (TRKC)，IC50值分别为 160，350，860，880 和 890 nM。 |
| IC50和靶点: | |
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DeNardo, D.G., Brennan, D.J., Rexhepaj, E., et al.Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapyCancer Discov.1(1),54-67(2011)
Coniglio, S.H., Eugenin, E., Dobrenis, K., et al.Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signalingMol. Med.18(1),519-527(2012)
