LF3

Cat. No.：YN450019

CAS No. ：664969-54-4

产品名称:	LF3
CAS No.:	664969-54-4
Chemical Name:	N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-1-piperazinecarbothioamide
Synonyms:	N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-1-piperazinecarbothioamide;LF-3;LF3
分子量:	416.56
分子式:	C₂₀H₂₄N₄O₂S₂
SMILES:	S=C(N1CCN(C/C=C/C2=CC=CC=C2)CC1)NC3=CC=C(S(=O)(N)=O)C=C3
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 98%

产品描述:	LF3是β-Catenin/TCF4相互作用的拮抗剂，具有抗肿瘤活性。IC50值为1.65 μM。
IC50和靶点:
In Vitro:
In Vivo:
Clinical Trial:
Solvent & Solubility:

Zhao, L., Sun, L., Lu, Y., et al.A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV 1.5 expression in HL-1 cardiomyocytesJ. Mol. Cell. Cardiol.135,90-96(2019)
Yu, Z., Jiang, X., Qin, L., et al.A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitinationOncogene40(5),1027-1042(2021)
Lei, Y., Yang, Q., Nie, Y., et al.Small-molecule inhibitor LF3 restrains the development of pulmonary hypertension through the Wnt/β-catenin pathwayActa Biochim Biophys. Sin. (Shanghai)53(10),(2021)