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WAY-262611

Cat. No.:YN450034

  • CAS No. :1123231-07-1

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    • 产品名称: WAY-262611
      CAS No.: 1123231-07-1
      Chemical Name: 1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine
      Synonyms:BML-WN110
      分子量:318.42
      分子式:C₂₀H₂₂N₄
      SMILES:NCC1CCN(C2=NC=CC(C3=CC=C4C=CC=CC4=C3)=N2)CC1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: WAY-262611是 Wnt/β- 联蛋白激动剂,可增加骨形成速率,在 TCF- 荧光素酶测定实验中的EC50值为0.63 μM。WAY-262611 也是Dkk1的抑制剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
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    • Polakis, P.Wnt signaling and cancerGenes Dev.14(15),1837-1851(2000)

      Reya, T., and Clevers, H.Wnt signalling in stem cells and cancerNature434(7035),834-850(2005)

      Clevers, H.Wnt/β-catenin signaling in development and diseaseCell127(3),469-480(2006)

      Hameed, A., Brady, J.J., Dowling, P., et al.Bone disease in multiple myeloma: pathophysiology and managementCancer Growth Metastasis7,33-42(2014)

      Pelletier, J.C., Lundquist, J.T.t., Gilbert, A.M., et al.(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a winglessβcatenin agonist that increases bone formation rateJ. Med. Chem.52(22),6962-6965(2009)

      Enochson, L., Stenberg, J., Brittberg, M., et al.GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibitionOsteoarthritis Cartilage22(4),566-577(2014)

      Choe, Y., Hun Kim, J., Park, K.Y., et al.Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid arthritisRheumatology (Oxford)55(5),928-938(2015)

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