D4476
Cat. No.：YN450022
CAS No. ：301836-43-1
规格
价格(RMB)
库存
| 产品名称: | D4476 |
| CAS No.: | 301836-43-1 |
| Chemical Name: | 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)1H-imidazol-2-yl]-benzamide |
| Synonyms: | Casein Kinase I Inhibitor |
| 分子量: | 398.41 |
| 分子式: | C₂₃H₁₈N₄O₃ |
| SMILES: | O=C(N)C1=CC=C(C=C1)C(N2)=NC(C3=CC=C4OCCOC4=C3)=C2C5=NC=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | D4476是具有有效性，选择性和细胞渗透性的CK1抑制剂，其在体外实验的IC50值为0.3 μM。 |
| IC50和靶点: | [{name:"CK1:0.3 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rena, G., Bain, J., Elliot, M., et al.D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1aEMBO reports5(1),60-65(2004)
Bain, J., Plater, L., Elliot, M., et al.The selectivity of protein kinase inhibitors: A further updateBiochem. J.408(3),297-315(2007)
Tillement, V., Lajoie-Mazenc, I., Casanova, A., et al.Phosphorylation of RhoB by CK1 impedes actin stress fiber organization and epidermal growth factor receptor stabilizationExp. Cell Res.314,2811-2821(2008)
MacLaine, N.J., Oster, B., Bundgaard, B., et al.A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infectionJ. Biol. Chem.283(42),28563-28573(2008)
Callahan, J.F., Burgess, J.L., Fornwald, J.A., et al.Identification of novel inhibitors of the transforming growth factor ß1 (TGF-ß1) type 1 receptor (ALK5)J. Med. Chem.45(5),999-1001(2002)
