IWP-2
Cat. No.：YN450088
CAS No. ：686770-61-6
规格
价格(RMB)
库存
| 产品名称: | IWP-2 |
| CAS No.: | 686770-61-6 |
| Chemical Name: | N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide |
| Synonyms: | IWP2 |
| 分子量: | 466.60 |
| 分子式: | C₂₂H₁₈N₄O₂S₃ |
| SMILES: | O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IWP-2 是Wnt加工和分泌的抑制剂，其IC50为 27 nM。IWP-2 靶向膜结合的 O-酰基转移酶 porcupine (Porcn)，从而阻止关键的 Wnt 配体棕榈糖基化。IWP-2 还是一种具有 ATP 竞争能力的CK1δ抑制剂，对于M82FCK1δ的IC50为 40 nM。 |
| IC50和靶点: | [{name:"CK1δ:40 nM (IC50)"}] |
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| Solvent & Solubility: |
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