Biphenylindanone A

Cat. No.：866823-73-6

CAS No. ：866823-73-6

产品名称:	Biphenylindanone A
CAS No.:	866823-73-6
Chemical Name:
Synonyms:	BINA
分子量:	454.56
分子式:	C₃₀H₃₀O₄
SMILES:	O=C(C1=CC=C(C2=CC=CC(COC3=CC4=C(C(C(C5CCCC5)C4)=O)C(C)=C3C)=C2)C=C1)O
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

Tresadern, G., Cid, J.M., Macdonald, G.J., et al.Scaffold hopping from pyridones to imidazo[1,2-α]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptorBioorg. Med. Chem. Lett.20(1),175-179(2010)', 'Galici, R., Jones, C.K., Hemstapat, K., et al.Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in miceJ. Pharmacol. Exp. Ther.318(1),173-185(2006)', 'Dhanya, R.P., Sidique, S., Sheffler, D.J., et al.Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in ratsJ. Med. Chem.54(1),342-353(2011)', 'Benneyworth, M.A., Xiang, Z., Smith, R.L., et al.A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosisMol. Pharmacol.72(2),477-484(2007)', 'Hackler, E.A., Byun, N.E., Jones, C.K., et al.Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activationNeuroscience168,209-218(2010)', 'Jin, X., Semenova, S., Yang, L., et al.The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in ratsNeuropsychopharmacology35(10),2021-2036(2010)