Aloisine RP106
Cat. No.：YN420360
| 产品名称: | Aloisine RP106 |
| CAS No.: | 496864-15-4 |
| Chemical Name: | 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine |
| Synonyms: | RP106; RP 106; RP-106 |
| 分子量: | 281.4 |
| 分子式: | C17H19N3O |
| SMILES: | COC(C=C1)=CC=C1C2=C(CCCC)C3=NC=CN=C3N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aloisine RP106 (compound 38) 是有效的Cdk1/cyclin B、Cdk5/p25和GSK3的抑制剂，IC50分别为 0.70µM、1.5µM、0.92 µM。 |
| IC50和靶点: | [{name:"Cdk1/cyclin B:0.7 μM (IC50)"},{name: "Cdk5/p25:1.5 μM (IC50)"},{name: "GSK-3:0.92 μM (IC50)"}] |
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Mettey, Y., Gompel, M., Thomas, V., et al.Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effectsJ. Med. Chem.46(2),222-236(2003)
