Perifosine
Cat. No.：YN420278
CAS No. ：157716-52-4
规格
价格(RMB)
库存
| 产品名称: | Perifosine |
| CAS No.: | 157716-52-4 |
| Chemical Name: | 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-piperidinium, inner salt |
| Synonyms: | 哌立福新; KRX-0401; NSC 639966; D21266 |
| 分子量: | 461.66 |
| 分子式: | C₂₅H₅₂NO₄P |
| SMILES: | [O-]P(OC1CC[N+](C)(CC1)C)(OCCCCCCCCCCCCCCCCCC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Perifosine是一种有口服活性的Akt抑制剂，抑制不同肿瘤细胞系增殖的IC50值为0.6-8.9 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ruiter, G.A., Zerp, S.F., Bartelink, H., et al.Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosisCancer Res.59,2457-2463(1999)
Kondapaka, S.B., Singh, S.S., Dasmahapatra, G.P., et al.Perifosine, a novel alkylphospholipid, inhibits protein kinase B activationMol. Cancer Ther.2,1093-1103(2003)
Patel, V., Lahusen, T., Sy, T., et al.Perifosine, a novel alkylphospholipid, induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrestCancer Res.62,1401-1409(2002)
