A-674563
Cat. No.：YN420361
CAS No. ：552325-73-2
| 产品名称: | A-674563 |
| CAS No.: | 552325-73-2 |
| Chemical Name: | αS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-benzeneethanamine |
| Synonyms: | A-674563; A 674563; A674563 |
| 分子量: | 358.4 |
| 分子式: | C22H22N4O |
| SMILES: | CC1=NNC(C1=C2)=CC=C2C3=CN=CC(OC[C@@H](N)CC4=CC=CC=C4)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-674563 是口服有效，选择性的Akt1抑制剂，Ki为 11 nM。 |
| IC50和靶点: | [{name:"Akt1:11 nM (Ki)"},{name: "PKA:16 nM (Ki)"},{name: "CDK2:46 nM (Ki)"},{name: "GSK3β:110 nM (Ki)"},{name: "ERK2:260 nM (Ki)"},{name: "PKCδ:360 nM (Ki)"},{name: "RSK2:580 nM (Ki)"},{name: "MAPK-AP2:1.1 μM (Ki)"},{name: "PKCγ:1.2 μM (Ki)"},{name: "Chk1:2.6 μM (Ki)"},{name: "CK2:5.4 μM (Ki)"},{name: "SRC:13 μM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Luo, Y., Shoemaker, A.R., Liu, X., et al.Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivoMol. Cancer Ther.4(6),977-968(2005)
