AS-041164
Cat. No.：YN420363
CAS No. ：6318-41-8
| 产品名称: | AS-041164 |
| CAS No.: | 6318-41-8 |
| Chemical Name: | 5-(1,3-benzodioxol-5-ylmethylene)-2,4-thiazolidinedione |
| Synonyms: | |
| 分子量: | 249.2 |
| 分子式: | C11H7NO4S |
| SMILES: | O=C(/C(S1)=C/C2=CC=C3C(OCO3)=C2)NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AS-041164 是一种有效的，选择性的，具有口服活性的PI3Kγ亚型抑制剂，IC50为 70 nM。AS-041164 对PI3Kα，PI3Kβ 和PI3Kδ的活性较低 (IC50分别为 240 nM，1.45 μM 和 1.70 μM)。AS-041164 具有抗炎作用。 |
| IC50和靶点: | [{name:"PI3Kγ:70 nM (IC50)"},{name: "PI3Kα:240 nM (IC50)"},{name: "PI3Kβ:1.4 μM (IC50)"},{name: "PI3Kδ:1.7 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hirsch, E., Ciraolo, E., Ghigo, A., et al.Taming the PI3K team to hold inflammation and cancer at bayPharmacol. Ther.118(2),192-205(2008)
Ferrandi, C., Ardissone, V., Ferro, P., et al.Phosphoinositide 3-kinase γ inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitmentJ. Pharmacol. Exp. Ther.322,923-930(2007)
