PKI-179
Cat. No.：YN420371
CAS No. ：1197160-28-3
| 产品名称: | PKI-179 |
| CAS No.: | 1197160-28-3 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 488.54 |
| 分子式: | C25H28N8O3 |
| SMILES: | O=C(NC1=CC=NC=C1)NC2=CC=C(C3=NC(N4C5CCC4COC5)=NC(N6CCOCC6)=N3)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PKI-179 是一种有效的和具有口服活性的双重PI3K/mTOR抑制剂，对PI3K-α，PI3K-β，PI3K-γ，PI3K-δ和mTOR的IC50值分别为 8 nM，24 nM，74 nM，77 nM 和 0.42 nM。PKI-179 还表现出对E545K和H1047R的活性，IC50值分别为 14 nM 和 11 nM。PKI-179 在体内显示出抗肿瘤活性。 |
| IC50和靶点: | [{name:"PI3Kα:8 nM (IC50)"},{name: "PI3Kβ:24 nM (IC50)"},{name: "PI3Kγ:74 nM (IC50)"},{name: "PI3Kδ:77 nM (IC50)"},{name: "mTOR:0.42 nM (IC50)"},{name: "E545K:14 nM (IC50)"},{name: "H1047R:11 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
