RMC-5552
Cat. No.：YN420376
| 产品名称: | RMC-5552 |
| CAS No.: | 2382768-62-7 |
| Chemical Name: | |
| Synonyms: | Rapamycin, 27-deoxo-27-hydroxy-, 42-[29-[6-[[4-amino-3-(2-amino-5-benzoxazolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-29-oxo-5,8,11,14,17,20,23,26-octaoxa-2-azanonacosanoate], |
| 分子量: | 1778.13 |
| 分子式: | C93H136N10O24 |
| SMILES: | C1C=C(C)[C@H](C[C@@]2(CC[C@H]([C@@](O)(O2)C(C(N2CCCC[C@@]2([H])C(=O)O[C@]([H])([C@@H](C[C@@H]2CC[C@H]([C@H](OC)C2)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)N2CC3=CC=C(CN4N=C(C5C6N=C(N)OC=6C=CC=5)C5C(N)=NC=NC4=5)C=C3CC2)C)C[C@@H](O)[C@@H](C=C([C@@H](O)[C@@H](O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RMC-5552 是一种有效的选择性mTORC1抑制剂。RMC-5552 抑制mTORC1pS6K和p4EBP1的磷酸化，IC50分别为 0.14 nM 和 0.48 nM。RMC-5552 表现出低得多的 pAKT 抑制作用 (IC50为 19 nM)，导致 mTORC1/mTORC2 选择性接近 40 倍。RMC-5552 具有抗癌活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
