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Metformin D6 hydrochloride

Cat. No.:YN420071

  • CAS No. :1185166-01-1

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    • 产品名称: Metformin D6 hydrochloride
      CAS No.: 1185166-01-1
      Chemical Name: N,N-dimethyl-d6-imidodicarbonimidic diamide, monohydrochloride
      Synonyms:1,1-Dimethylbiguanide D6 hydrochloride
      分子量:171.66
      分子式:C₄H₆D₆ClN₅
      SMILES:NC(NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=N)=N.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Metformin D6 hydrochloride是 Metformin hydrochloride 的一种氘代化合物。Metformin hydrochloride抑制肝脏中的线粒体呼吸链,导致AMPK活化,增强胰岛素敏感性,可用于 2 型糖尿病的研究。Metformin hydrochloride 可以透过血脑屏障,诱导自噬 (autophagy)。
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    • Viollet, B., Guigas, B., Garcia, N.S., et al.Cellular and molecular mechanisms of metformin: An overviewClin. Sci. (Lond.)122(6),253-270(2012)

      Shaw, R.J., Lamia, K.A., Vasquez, D., et al.The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminScience310,1642-1646(2005)

      Wheaton, W.W., Weinberg, S.E., Hamanaka, R.B., et al.Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisElife3:e02242,(2014)

      Kim, E.K., Lee, S.H., Jhun, J.Y., et al.Metformin prevents fatty liver and improves balance of white/brown adipose in an obesity mouse model by inducing FGF21.Mediators Inflamm.5813030,(2016)

      Lin, M.-J., Dai, W., Scott, M.J., et al.Metformin improves nonalcoholic fatty liver disease in obese mice via down-regulation of apolipoprotein A5 as part of the AMPK/LXRα signaling pathwayOncotarget8\(65),108802-108809(2017)

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