Buformin hydrochloride
Cat. No.：YN420287
CAS No. ：1190-53-0
规格
价格(RMB)
库存
| 产品名称: | Buformin hydrochloride |
| CAS No.: | 1190-53-0 |
| Chemical Name: | N-butyl-imidodicarbonimidic diamide, monohydrochloride |
| Synonyms: | 盐酸丁双胍; 1-Butylbiguanide hydrochloride |
| 分子量: | 193.68 |
| 分子式: | C₆H₁₆ClN₅ |
| SMILES: | NC(NC(NCCCC)=N)=N.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Buformin hydrochloride (1-Butylbiguanide hydrochloride) 是一种有效的，具有口服活性的降血糖试剂 (antidiabetic agent)，是一种AMPK活化剂。Buformin 降低肝糖异生并降低血糖生成。Buformin 也具有抗癌活性，可以应用于癌症研究，如宫颈癌、乳腺癌等。 |
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Miller, R.A., Chu, Q., Xie, J., et al.Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMPNature494(7436),256-260(2013)
Yano, A., Kubota, M., Iguchi, K., et al.Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenaseBiol. Pharm. Bull.29(5),1006-1009(2006)
Bridges, H.R., Jones, A.J.Y., Pollak, M.N., et al.Effects of metformin and other biguanides on oxidative phosphorylation in mitochondriaBiochem. J.462(3),475-487(2014)
Saito, S., Furuno, A., Sakurai, J., et al.Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivationCancer Res.69(10),4225-4234(2015)
