Bongkrekic acid
Cat. No.：YN360448
CAS No. ：11076-19-0
| 产品名称: | Bongkrekic acid |
| CAS No.: | 11076-19-0 |
| Chemical Name: | 20-(carboxymethyl)-6R-methoxy-2,5,17S-trimethyl-2E,4Z,8Z,10E,14E,18E,20Z-docosaheptaenedioic acid |
| Synonyms: | |
| 分子量: | 486.60 |
| 分子式: | C₂₈H₃₈O₇ |
| SMILES: | OC(CC(/C=C/[C@@H](C)C/C=C/CC/C=C/C=C\C[C@@H](OC)/C(C)=C\C=C(C)\C(O)=O)=C/C(O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bongkrekic acid 是一种由假单胞菌分泌的线粒体毒素 (mitochondrial toxin)。Bongkrekic acid 是线粒体腺嘌呤核苷酸 (ADP/ATP) 转位酶 (ANT) 的特异性配体而不是电子传递链的。Bongkrekic acid 必须通过线粒体内膜产生抑制 ADP/ATP 转运的作用。 |
| IC50和靶点: | |
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Henderson, P.J.F., and Lardy, H.A.Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of mitochondriaJ. Biol. Chem.245(6),1319-1326(1970)
Xie, X., Khosla, C., and Cane, D.E.Elucidation of the stereospecificity of C-methyltransferases from trans-at polyketide synthasesJ. Am. Chem. Soc.139(17),6102-6105(2017)
Lauqin, G.J., Dulpaa, A.M., Klein, G., et al.Isobongkrekic acid, a new inhibitor of mitochondrial ADP-ATP transport: Radioactive labeling and chemical and biological propertiesBiochemistry15(11),2323-2327(1976)
Kligenberg, M., Grebe, K., and Heldt, H.W.On the inhibition of the adenine nucleotide translocation by bongkrekic acidBiochem. Biophys. Res. Commun.39(3),344-351(1970)
Ruprecht, J.J., King, M.S., Zögg, T., et al.The molecular mechanism of transport by the mitochondrial ADP/ATP carrierCell176(3),435-447(2019)
Takeda, S., Okazaki, H., Kudo, T., et al.Bongkrekic acid as a warburg effect modulator in long-term estradiol-deprived MCF-7 breast cancer cellsAnticancer Res.36(10),5171-5182(2016)
Hu, W.J., Zhang, G.S., Chu, F.S., et al.Purification and partial characterization of flavotoxin AAppl. Environ. Microbiol.48(4),690-693(1984)
