680C91
Cat. No.：YN1730138
CAS No. ：163239-22-3
规格
价格(RMB)
库存
| 产品名称: | 680C91 |
| CAS No.: | 163239-22-3 |
| Chemical Name: | 6-fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole |
| Synonyms: | |
| 分子量: | 238.2597232 |
| 分子式: | C15H11FN2 |
| SMILES: | FC1=CC=C2C(/C=C/C3=CN=CC=C3)=CNC2=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 680C91 是一种口服有效的，选择性色氨酸 2,3-双加氧酶 (TDO) 抑制剂，Ki为 51 nM。TDO 是色氨酸分解代谢的关键酶。680C91 可用于肿瘤免疫和阿尔茨海默症的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Pilotte, L., Larrieu, P., Stroobant, V., et al.Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenaseProc. Natl. Acad. Sci. USA109(7),2497-2502(2012)
Cecchi, M., Paccosi, S., Silvano, A., et al.Dexamethasone induces the expression and function of tryptophan-2-3-dioxygenase in SK-MEL-28 melanoma cellsPharmaceuticals (Basel)14(3),211(2021)
Salter, M., Hazelwood, R., Pogson, C.I., et al.The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the ratBiochem. Pharmacol.49(10),1435-1442(1995)
