Tirbanibulin
Cat. No.：YN440083
CAS No. ：897016-82-9
规格
价格(RMB)
库存
| 产品名称: | Tirbanibulin |
| CAS No.: | 897016-82-9 |
| Chemical Name: | 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide |
| Synonyms: | KX2-391; KX-01 |
| 分子量: | 431.53 |
| 分子式: | C₂₆H₂₉N₃O₃ |
| SMILES: | O=C(CC1=NC=C(C2=CC=C(OCCN3CCOCC3)C=C2)C=C1)NCC4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tirbanibulin (KX2-391) 是一种拟肽类Src抑制剂，靶向 Src 的多肽底物结合位点，对多种癌细胞株 GI50为 9-60 nM。 |
| IC50和靶点: | |
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Naing, A., Cohen, R., Dy, G.K., et al.A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignanciesInvest. New Drugs31(4),967-973(2013)
Anbalagan, M., Carrier, L., Glodowski, S., et al.KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancerBreast Cancer Res. Treat.132(2),391-409(2012)
Lau, G.M., Lau, G.M., Yu, G.-L., et al.Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitroDig. Dis. Sci.54(7),1465-1474(2009)
Wang, P., Xiao, X., Zhang, Y., et al.A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemiaJ. Hematol. Oncol.14(1),105(2021)
