Sparsentan
Cat. No.：YN321170
CAS No. ：254740-64-2
| 产品名称: | Sparsentan |
| CAS No.: | 254740-64-2 |
| Chemical Name: | 4′-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2′-(ethoxymethyl)-[1,1′-biphenyl]-2-sulfonamide |
| Synonyms: | RE-021; DARA-a |
| 分子量: | 592.75 |
| 分子式: | C₃₂H₄₀N₄O₅S |
| SMILES: | O=S(C1=CC=CC=C1C2=CC=C(CN3C(CCCC)=NC4(CCCC4)C3=O)C=C2COCC)(NC5=NOC(C)=C5C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sparsentan (RE-021) 是高度选择的血管紧张素 II (angiotensin II) 和内皮素 A (endothelin A) 受体的双重拮抗剂，Ki值分别为 0.8 和 9.3 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Murugesan, N., Gu, Z., Fadnis, L., et al.Dual angiotensin II and endothelin A receptor antagonists: Synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokineticsJ. Med. Chem.48(1),171-179(2005)
Nagasawa, H., Suzuki, H., Jenkinson, C., et al.The dual endothelin ETA and angiotensin AT1 receptor blocker sparsentan protects against the development of albuminuria and glomerulosclerosis in the gddY mouse model of IgANephrol. Dial. Transplant.35(Suppl. 3),P0348(2020)
