CK-869
Cat. No.：YN300044
CAS No. ：388592-44-7
| 产品名称: | CK-869 |
| CAS No.: | 388592-44-7 |
| Chemical Name: | 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone |
| Synonyms: | 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one;CK 869;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone;CK-0157869;CK-869 |
| 分子量: | 394.28 |
| 分子式: | C₁₇H₁₆BrNO₃S |
| SMILES: | O=C1N(C2=CC=C(OC)C=C2OC)C(C3=CC=CC(Br)=C3)SC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CK-869 是肌动蛋白相关蛋白 2/3 复合体(ARP2/3)的抑制剂，其IC50值为 7 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ilatovskaya, D.V., Chubinskiy-Nadexhdin, V., Pavlov, T.S., et al.Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cellsCell Tissue Res.354(3),783-792(2013)
Nolen, B.J., Tomasevic, N., Russell, A., et al.Characterization of two classes of small molecule inhibitors of Arp2/3 complexNature460(7258),1031-1034(2009)
Beckham, Y., Vasquez, R.J., Stricker, J., et al.Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assemblyPLOS one9(6),e100943(2014)
