Cytochalasin B
Cat. No.：YN300045
CAS No. ：14930-96-2
| 产品名称: | Cytochalasin B |
| CAS No.: | 14930-96-2 |
| Chemical Name: | (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione |
| Synonyms: | 细胞松弛素B; Phomin |
| 分子量: | 479.61 |
| 分子式: | C₂₉H₃₇NO₅ |
| SMILES: | O=C1N[C@@H](CC2=CC=CC=C2)[C@@]3([H])[C@]14[C@](/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(O4)=O)([H])[C@H](O)C([C@H]3C)=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cytochalasin B 是一种能透过细胞的真菌毒素，能够与肌动蛋白丝的有刺端结合，扰乱肌动蛋白聚合物的形成，对 F-actin 的Kd值为 1.4-2.2 nM。 |
| IC50和靶点: | |
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Theodoropoulos, P.A., Gravanis, A., Tsapara, A., et al.Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end cappingBiochem. Pharmacol.47(10),1875-1881(1994)
Steinberg, M.S., and Wiseman, L.L.Do morphogenetic tissue rearrangements require active cell movements? The reversible inhibition of cell sorting and tissue spreading by cytochalasin BJ. Cell Biol.55,606-615(1972)
Spudich, J.A., and Lin, S.Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement/microfilaments/rabbit striated muscle)Proc. Natl. Acad. Sci. USA69(2),442-446(1972)
Estensen, R.D., and Plagemann, P.G.W.Cytochalasin B: Inhibition of glucose and glucosamine transportProc. Natl. Acad. Sci. USA69(6),1430-1434(1972)
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