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Genipin

Cat. No.：6902-77-8

  • CAS No. ：6902-77-8

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    • 产品名称: Genipin
      CAS No.: 6902-77-8
      Chemical Name:
      Synonyms:京尼平; (+)
      分子量:226.23
      分子式:C₁₁H₁₄O₅
      SMILES:O=C(C1=CO[C@@H](O)[C@@]2([H])[C@]1([H])CC=C2CO)OC
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Chan, C.B., De Leo, D., Joseph, J.W., et al.Increased uncoupling protein-2 levels in ß-cells are associated with impaired glucose-stimulated insulin secretion mechanism of actionDiabetes50(6),1302-1310(2001)', 'Zhang, C.Y., Baffy, G., Perret, P., et al.Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, ß cell dysfunction, and type 2 diabetesCell105(6),745-755(2001)', 'Sesti, G., Cardellini, M., Marini, M.A., et al.A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjectsDiabetes52(5),1280-1283(2003)', 'Parton, L.E., Ye, C.P., Coppari, R., et al.Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesityNature449(7159),228-232(2007)', 'Zhang, C.Y., Parton, L.E., Ye, C.P., et al.Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity-and high glucose-induced ß cell dysfunction in isolated pancreatic isletsCell Metab.3(6),417-427(2006)', 'Kim, B.C., Kim, H.G., Lee, S.A., et al.Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathwayBiochem. Pharmacol.70(9),1398-1407(2005)
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