KPT-185
Cat. No.：YN360552
CAS No. ：1333151-73-7
| 产品名称: | KPT-185 |
| CAS No.: | 1333151-73-7 |
| Chemical Name: | 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2Z-propenoic acid, 1-methylethyl ester |
| Synonyms: | KPT 185,KPT-185 |
| 分子量: | 355.31 |
| 分子式: | C₁₆H₁₆F₃N₃O₃ |
| SMILES: | O=C(OC(C)C)/C=C\N1N=C(C2=CC(C(F)(F)F)=CC(OC)=C2)N=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KPT-185 是一种口服生物可利用的CRM1选择性抑制剂，在亚微摩尔浓度下显示出有效的抗增殖特性 (IC50=100-500 nM)，诱导 AML 细胞系和患者母细胞凋亡、细胞周期停滞和髓样分化。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ranganathan, P., Yu, X., Na, C., et al.Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemiaBlood120(9),1765-1773(2012)
Etchin, J., Sanda, T., Mansour, M.R., et al.KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemiaBr. J. Haematol.161(1),117-127(2013)
Wang, S., Han, X., Wang, J., et al.Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenograftsPLoS One9(3),e89848(2014)
