Leptomycin B
Cat. No.：YN360593
CAS No. ：87081-35-4
| 产品名称: | Leptomycin B |
| CAS No.: | 87081-35-4 |
| Chemical Name: | 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,10E,12E,16Z,18E-nonadecapentaenoic acid |
| Synonyms: | 来普霉素B; CI 940; LMB |
| 分子量: | 540.73 |
| 分子式: | C₃₃H₄₈O₆ |
| SMILES: | O=C(O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(CC)\C=C\[C@H]1[C@@H](C)C=CC(O1)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Leptomycin B (CI 940; LMB) 是一种蛋白出核转运抑制剂。Leptomycin 通过半胱氨酸残基处的共价修饰使CRM1/exportin 1失活。 Leptomycin B 是一种有效的抗真菌抗生素，可阻断真核细胞周期。 |
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Kudo, N., Wolff, B., Sekimoto, T., et al.Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1Exp. Cell Res.242(2),540-547(1998)
Nishi, K., Yoshida, M., Fujiwara, D., et al.Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expressionJ. Biol. Chem.269(9),6320-6324(1994)
Smart, P., Lane, E.B., Lane, D.P., et al.Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin BOncogene18,7378-7386(1999)
