KPT-276
Cat. No.：YN360635
CAS No. ：1421919-75-6
| 产品名称: | KPT-276 |
| CAS No.: | 1421919-75-6 |
| Chemical Name: | (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-2-propen-1-one |
| Synonyms: | KPT-276,KPT 276 |
| 分子量: | 426.26 |
| 分子式: | C₁₆H₁₀F₈N₄O |
| SMILES: | O=C(N1CC(F)(F)C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KPT-276 是KPT-185的类似物，是一种口服生物可利用的核输出选择性抑制剂（SINE），它不可逆地与CRM1结合并阻断CRM1的功能。 |
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| Solvent & Solubility: |
Ranganathan, P., Yu, X., Na, C., et al.Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemiaBlood120(9),1765-1773(2012)
Green, A.L., Ramkissoon, S.H., McCauley, D., et al.Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastomaNeuro. Oncol.17(5),697-707(2015)
