KN-93
Cat. No.：YN380108
CAS No. ：139298-40-1
| 产品名称: | KN-93 |
| CAS No.: | 139298-40-1 |
| Chemical Name: | N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide |
| Synonyms: | KN-93，KN93,KN 93 |
| 分子量: | 501.04 |
| 分子式: | C₂₆H₂₉ClN₂O₄S |
| SMILES: | O=S(C1=CC=C(OC)C=C1)(N(C2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)CCO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KN-93是可渗透细胞，可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂，Ki为370 nM。 |
| IC50和靶点: | |
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Sumi, M., Kiuchi, K., Ishikawa, T., et al.The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cellsBiophys. Res. Commun.181(3),968-975(1991)
Mamiya, N., Goldenring, J.R., Tsunoda, Y., et al.Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93Biophys. Res. Commun.195(2),608-615(1993)
Oestreich, E.A., Malik, S., Goonasekera, S.A., et al.Epac and phospholipase Cε regulate Ca2+ release in the heart by activation of protein kinase Cε and calcium-calmodulin kinase IIJ. Biol. Chem.284(3),1514-1522(2009)
Flamand, N., Luo, M., Peters-Golden, M., et al.Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear exportJ. Biol. Chem.284(1),306-313(2009)
Riganti, C., Doublier, S., Viarisio, D., et al.Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1α and P-glycoprotein overexpressionBr. J. Pharmacol.156(7),1054-1066(2009)
