MLCK inhibitor peptide 18
Cat. No.：YN380282
CAS No. ：224579-74-2
| 产品名称: | MLCK inhibitor peptide 18 |
| CAS No.: | 224579-74-2 |
| Chemical Name: | L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide |
| Synonyms: | |
| 分子量: | 1324.62 |
| 分子式: | C₆₀H₁₀₅N₂₃O₁₁ |
| SMILES: | [K][R]([Y]([Y][R][R](N)[K])[K])[K] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MLCK inhibitor peptide 18 是一种有效的MLCK抑制剂，IC50值为 50 nM，同时较弱抑制CaM kinase II的活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lukas, T.J., Mirzoeva, S., Slomczynska, U., et al.Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledgeJ. Med. Chem.42(5),910-919(1999)
Zolotarevsky, Y., Hecht, G., Koutsouris, A., et al.A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal diseaseGastroenterology123(1),163-172(2002)
Deng, M., Williams, C.J., and Schultz, R.M.Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarityDev. Biol.278(2),358-366(2005)
Gitik, M., Reichert, F., and Rotschenker, S.Cytoskeleton plays a dual role of activation and inhibition in myelin and zymosan phagocytosis by microgliaFASEB J.24(7),2211-2221(2010)
