BML-190
Cat. No.：YN320984
CAS No. ：2854-32-2
| 产品名称: | BML-190 |
| CAS No.: | 2854-32-2 |
| Chemical Name: | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-ethanone |
| Synonyms: | 吲哚美辛吗啉代酰胺; Indomethacin morpholinylamide; IMMA |
| 分子量: | 426.89 |
| 分子式: | C₂₃H₂₃ClN₂O₄ |
| SMILES: | CC(N1C(C2=CC=C(Cl)C=C2)=O)=C(CC(N3CCOCC3)=O)C4=C1C=CC(OC)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BML-190(IMMA)是CB2受体的配体，对CB2和CB1受体的Ki分别为435 nM和> 2 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gallant, M., Dufresne, C., Gareau, Y., et al.New class of potent ligands for the human peripheral cannabinoid receptorBioor. Med. Chem. Lett.6(19),2263-2268(1996)
New, D.C., and Wong, Y.H.BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: Signalling via cAMP and inositol phosphatesFEBS Lett.536(1-3),157-160(2003)
Chang, Y.-H., Lee, S.T., and Lin, W.-W.Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: Involvement of eicosanoidsJ. Cell. Biochem.81(4),715-723(2001)
