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2-HBA

Cat. No.:YN270055

  • CAS No. :131359-24-5

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    • 生物活性
    • 参考文献
    • 产品名称: 2-HBA
      CAS No.: 131359-24-5
      Chemical Name: (1E,4E)-1,5-bis(2-hydroxyphenyl)-1,4-pentadien-3-one
      Synonyms:
      分子量:266.29
      分子式:C₁₇H₁₄O₃
      SMILES:O=C(/C=C/C1=CC=CC=C1O)/C=C/C2=CC=CC=C2O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: 2-HBA 是一个有效的 NAD(P)H: 醌受体氧化还原酶 1 (NQO1) 诱导剂,也可以激活半胱天冬酶-3 (caspase-3) 和半胱天冬酶-10 (caspase-10)。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Wang, R., Kern, J.T., Goodfriend, T.L., et al.Activation of the antioxidant response element by specific oxidized metabolites of linoleic acidProstaglandins Leukot. Essent. Fatty Acids81(1),53-59(2009)

      Gao, L., Wang, J., Sekhar, K.R., et al.Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3J. Biol. Chem.282(4),2529-2537(2007)

      Taguchi, K., Motohashi, H., and Yamamoto, M.Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolutionGenes Cells16(2),123-140(2011)

      Magesh, S., Chen, Y., and Hu, L.Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsMed. Res. Rev.32(4),687-726(2012)

      Dinkova-Kostova, A.T., Cory, A.H., Bozak, R.E., et al.Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathwayCancer Lett.245(1-2),341-349(2007)

      Dinkova-Kostova, A.T., Holtzclaw, W.D., Cole, R.N., et al.Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsProc. Natl. Acad. Sci. USA99(18),11908-11913(2012)

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    稀释计算器 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
    • C1
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      C2
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