Z-Asp-CH2-DCB
Cat. No.：YN270124
| 产品名称: | Z-Asp-CH2-DCB |
| CAS No.: | 153088-73-4 |
| Chemical Name: | (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester 2,6-dichloro-benzoic acid |
| Synonyms: | Z-Asp-CH2-DCB; PASE-1 INHIBITOR V; FHN88734; FHN-88734; FHN 88734; |
| 分子量: | 454.26 |
| 分子式: | C₂₀H₁₇Cl₂NO₇ |
| SMILES: | O=C(OCC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(O)=O)=O)C2=C(Cl)C=CC=C2Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Z-Asp-CH2-DCB 是一种不可逆的广谱caspase抑制剂，Z-Asp-CH2-DCB 也能抑制具有 caspase 样活性的蛋白酶。Z-D-CH2-DCB 并以剂量依赖的方式阻断 PBMC 细胞中的金黄色葡萄球菌肠毒素 B (SEB) 刺激的 IL-1β、TNF-α、IL-6 和 IFN-γ 的产生，和降低 SEB-1 刺激的 T 细胞增殖。Z-Asp-CH2-DCB 可预防 SU5416 诱导的间隔细胞凋亡和肺气肿的发生。 |
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Dolle, R.E., Hoyer, D., Prasad, C.V.C., et al.P1 aspartate-based peptide α-((2,6dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1β-converting enzymeJ. Med. Chem.37(5),563-564(1994)
Mashima, T., Naito, M., Kataoka, S., et al.Aspartate-based inhibitor of interleukin-1-β-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cellsBiochem. Biophys. Res. Commun.209(3),907-915(1995)
Krakauer, T.Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferationClin. Diagn. Lab. Immunol.11(3),621-624(2004)
