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Aprocitentan

Cat. No.：1103522-45-7

  • CAS No. ：1103522-45-7

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    • 产品名称: Aprocitentan
      CAS No.: 1103522-45-7
      Chemical Name:
      Synonyms:ACT-132577
      分子量:546.19
      分子式:C₁₆H₁₄Br₂N₆O₄S
      SMILES:O=S(N)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Dingemanse, J., Sidharta, P.N., Maddrey, W.C., et al.Efficacy, safety and clinical pharmacology of macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertensionExpert Opin. Drug Saf.13(3),391-405(2013)', 'Iglarz, M., Binkert, C., Morrison, K., et al.Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonistJ. Pharmacol. Exp. Ther.327(3),736-745(2008)', 'Cutolo, M., Montagna, P., Brizzolara, R., et al.Effects of macitentan and its active metabolite on cultured human systemic sclerosis and control skin fibroblastsJ. Rheumatol.42(3),456-463(2015)', 'Trensz, F., Bortolamiol, C., Kramberg, M., et al.Pharmacological characterization of aprocitentan, a dual endothelin receptor antagonist, alone and in combination with blockers of the renin angiotensin system, in two models of experimental hypertensionJ. Pharmacol. Exp. Ther.368(3),462-473(2019)
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