PF-431396
Cat. No.：YN440097
CAS No. ：717906-29-1
规格
价格(RMB)
库存
| 产品名称: | PF-431396 |
| CAS No.: | 717906-29-1 |
| Chemical Name: | N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide |
| Synonyms: | PF 431396，PF431396 |
| 分子量: | 506.50 |
| 分子式: | C₂₂H₂₁F₃N₆O₃S |
| SMILES: | CS(=O)(N(C)C1=CC=CC=C1CNC2=NC(NC3=CC4=C(C=C3)NC(C4)=O)=NC=C2C(F)(F)F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-431396 是具有口服活性的FAK和Pyk2的抑制剂，其IC50值分别为 2 nM 和 11 nM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Han, S., Mistry, A., Chang, J.S., et al.Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor designJ. Biol. Chem.284(19),13193-13201(2009)
Buckbinder, L., Crawford, D.T., Qi, H., et al.Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosisProc. Natl. Acad. Sci. USA104(25),10619-10624(2007)
