Defactinib
Cat. No.：YN440200
CAS No. ：1073154-85-4
规格
价格(RMB)
库存
| 产品名称: | Defactinib |
| CAS No.: | 1073154-85-4 |
| Chemical Name: | N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-benzamide |
| Synonyms: | VS-6063; PF-04554878 |
| 分子量: | 510.49 |
| 分子式: | C₂₀H₂₁F₃N₈O₃S |
| SMILES: | O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Defactinib (VS-6063; PF-04554878) 是一种新型FAK抑制剂，抑制 FAK 在 Tyr397 位点磷酸化，这种作用具有时间和剂量依赖性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Schwock, J., Dhani, N., and Hedley, D.W.Targeting focal adhesion kinase signaling in tumor growth and metastasisExpert Opin. Ther. Targets14(1),77-94(2010)
Lee, B.Y., Timpson, P., Horvath, L.G., et al.FAK signaling in human cancer as a target for therapeuticsPharmacol. Ther.146,132-149(2015)
Kang, Y., Hu, W., Ivan, C., et al.Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancerJNCI105(19),1485-1495(2013)
