PND-1186
Cat. No.：YN440298
CAS No. ：1061353-68-1
| 产品名称: | PND-1186 |
| CAS No.: | 1061353-68-1 |
| Chemical Name: | 2-[[2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methyl-benzamide |
| Synonyms: | VS-4718; SR-2516 |
| 分子量: | 501.50 |
| 分子式: | C₂₅H₂₆F₃N₅O₃ |
| SMILES: | O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2C(F)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PND-1186 (VS-4718; SR-2516) 是有效可逆的FAK抑制剂，细胞试验中的IC50为1.5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tanjoni, I., Walsh, C., Uryu, S., et al.PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environmentsCancer Biol. Ther.9(10),764-777(2010)
Walsh, C., Tanjoni, I., Uryu, S., et al.Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical modelsCancer Biol. Ther.9(10),778-790(2010)
