TM-N1324
Cat. No.：YN320380
CAS No. ：1144477-35-9
| 产品名称: | TM-N1324 |
| CAS No.: | 1144477-35-9 |
| Chemical Name: | 4-(2-chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one |
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| 分子量: | 397.79 |
| 分子式: | C₁₈H₁₃ClFN₇O |
| SMILES: | O=C1CC(C2=CC=C(F)C=C2Cl)C3=C(N(C4=C5N=CNC5=NC=N4)N=C3C)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TM-N1324 是 G 蛋白偶联受体 39 (GPR39) 的激动剂，在 Zn2+存在的情况下，对人和鼠GPR39的EC50值分别为 9 nM 和 5 nM，在 Zn2+不存在的情况下，对人和鼠GPR39的EC50值分别为 280 nM 和 180 nM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Frimurer, T.M., Mende, F., Graae, A.-S., et al.Model-based discovery of synthetic agonists for the Zn2+-sensing G-protein-coupled receptor 39 (GPR39) reveals novel biological functionsJ. Med. Chem.60(3),886-898(2017)
Grunddal, K.V., Diep, T.A., Petersen, N., et al.Selective release of gastrointestinal hormones induced by an orally active GPR39 agonistMol. Metab.49,101207(2021)
