Branaplam hydrochloride
Cat. No.：YN290853
CAS No. ：1562338-39-9
规格
价格(RMB)
库存
| 产品名称: | Branaplam hydrochloride |
| CAS No.: | 1562338-39-9 |
| Chemical Name: | |
| Synonyms: | LMI070 hydrochloride; NVS-SM1 hydrochloride |
| 分子量: | 429.94 |
| 分子式: | C22H28ClN5O2 |
| SMILES: | OC1C=C(C2=CNN=C2)C=CC=1C1N=NC(OC2CC(C)(C)NC(C)(C)C2)=CC=1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Branaplam (LMI070; NVS-SM1) hydrochloride 是一种口服有效和选择性的SMN2拼接调节剂，对 SMN 的EC50为 20 nM。Branaplam hydrochloride 抑制hERG，IC50为 6.3 μM。Branaplam hydrochloride 在严重的脊髓性肌萎缩症 (SMA) 小鼠模型中可提高全长 SMN 蛋白并延长其生存期。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
