Takinib
Cat. No.：YN350031
CAS No. ：1111556-37-6
| 产品名称: | Takinib |
| CAS No.: | 1111556-37-6 |
| Chemical Name: | N1-(1-propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide |
| Synonyms: | EDHS-206 |
| 分子量: | 322.36 |
| 分子式: | C₁₈H₁₈N₄O₂ |
| SMILES: | CCCN1C2=CC=CC=C2N=C1NC(C3=CC(C(N)=O)=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Takinib 是一种有效且有选择性的TAK1抑制剂，其IC50值为 9.5 nM，Takinib 抑制自身磷酸化和非磷酸化 TAK1，其结合在 ATP结合口袋内并通过减慢 TAK1 活化的限速步骤来抑制。 |
| IC50和靶点: | [{name:"TAK1:9.5 nM (IC50)"},{name: "IRAK4:120 nM (IC50)"},{name: "IRAK1:390 nM (IC50)"},{name: "GCK:430 nM (IC50)"},{name: "CLK2:430 nM (IC50)"},{name: "MINK1:1.9 μM (IC50)"}] |
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Totzke, J., Gurbani, D., Raphemot, R., et al.Takinib, a selective TAK1 inhibitor, broadens the therapeutic efficacy of TNF-α inhibition for cancer and autoimmune diseaseCell Chem. Biol.24(8),1029-1039(2017)
Scarneo, S.A., Eibschutz, L.S., Bendele, P.J., et al.Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA miceArthritis Res. Ther.21(1),292(2019)
