Tpl2 Kinase Inhibitor 1
Cat. No.：YN350110
| 产品名称: | Tpl2 Kinase Inhibitor 1 |
| CAS No.: | 871307-18-5 |
| Chemical Name: | 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile |
| Synonyms: | |
| 分子量: | 404.83 |
| 分子式: | C₂₁H₁₄ClFN₆ |
| SMILES: | N#CC1=C(NC2=CC=C(F)C(Cl)=C2)C3=CC(NCC4=CC=CN=C4)=NC=C3N=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tpl2 Kinase Inhibitor 1 (Compound 1) 是一种有效的选择性Tpl2(COT激酶，MAP3K8) 抑制剂，可用于炎症反应和某些癌症的研究。 |
| IC50和靶点: | |
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Garvin, L.K., Green, N., Hu, Y., et al.Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure-activity relationshipsBioor. Med. Chem. Lett.15(23),5288-5292(2005)
Wang, X., and Studzinski, G.P.Expression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cellsJ. Steroid. Biochem. Mol. Biol.121(1-2),395-398(2010)
Wang, X., Gocek, E., Novik, V., et al.Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3Cell Cycle9(22),4542-4551(2010)
