SHU 9119
Cat. No.：YN321815
| 产品名称: | SHU 9119 |
| CAS No.: | 168482-23-3 |
| Chemical Name: | N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2→7)-lactam, trifluoroacetate salt |
| Synonyms: | SHU9119 |
| 分子量: | 1074.24 |
| 分子式: | C₅₄H₇₁N₁₅O₉ |
| SMILES: | [Ac-{Nle}-cyclo[DH-D-{Nal}-RWK]-NH2] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SHU 9119 是有效地人类黑皮素受体 3 和 4 (MC3/4R) 拮抗剂，同时也是MC5R的部分激动剂，对人类 MC3R, MC4R 和 MC5R 的IC50值分别为 0.23, 0.06 和 0.09 nM。 |
| IC50和靶点: | |
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Yang, Y., Chen, M., Lai, Y., et al.Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activityJ. Biol. Chem.277(23),20328-20335(2002)
Nogueiras, R., Wiedmer, P., Perez-Tilve, D., et al.The central melanocortin system directly controls peripheral lipid metabolismJ. Clin. Invest.117(11),3475-3488(2007)
Kooijman, S., Boon, M.R., Parlevliet, E.T., et al.Inhibition of the central melanocortin system decreases brown adipose tissue activityJ. Lipid Res.55(10),2022-2032(2014)
