WZ4003
Cat. No.：YN420225
CAS No. ：1214265-58-3
规格
价格(RMB)
库存
| 产品名称: | WZ4003 |
| CAS No.: | 1214265-58-3 |
| Chemical Name: | N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-propanamide |
| Synonyms: | WZ 4003,WZ4003 |
| 分子量: | 496.99 |
| 分子式: | C₂₅H₂₉ClN₆O₃ |
| SMILES: | O=C(NC1=CC=CC(OC2=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=C1)CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WZ4003 是一种有效的，高度特异性的NUAK kinase抑制剂，能够抑制 NUAK1 (ARK5)/NUAK2 的活性，IC50值分别为 20 nM/100 nM。 |
| IC50和靶点: | [{name:"NUAK1:20 nM (IC50)"},{name: "NUAK2:100 nM (IC50)"}] |
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| Solvent & Solubility: |
Banerjee, S., Buhrlage, S.J., Huang, H.T., et al.Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinasesBiochem. J.457(1),215-225(2014)
