Cinobufotalin
Cat. No.：YN482595
| 产品名称: | Cinobufotalin |
| CAS No.: | 1108-68-5 |
| Chemical Name: | 16β-(acetyloxy)-14,15β-epoxy-3β,5β-dihydroxy-bufa-20,22-dienolide |
| Synonyms: | 华蟾毒它灵 |
| 分子量: | 458.54 |
| 分子式: | C₂₆H₃₄O₇ |
| SMILES: | C[C@]([C@@H](C(C=C1)=COC1=O)[C@H]2OC(C)=O)(CC[C@@]3([H])[C@@]4([H])CC[C@@]5(O)[C@@]3(CC[C@H](O)C5)C)[C@@]64[C@@H]2O6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cinobufotalin 是强心类固醇或丁二烯内酯，是从蟾蜍的皮肤分泌物中提取的。Cinobufotalin 已被用作强心药，利尿药和止血药，也是潜在的抗肺癌药物。 |
| IC50和靶点: | |
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Wang, Y., Lonard, D.M., Yu, Y., et al.Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1Cancer Res.74(5),1506-1517(2014)
Akimova, O.A., Bagrov, A.Y., Lopina, O.D., et al.Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cellsJ. Biol. Chem.280(1),832-839(2005)
Chen, L., Mai, W., Chen, M., et al.Arenobufagin inhibits prostate cancer epithelial-mesenchymal transition and metastasis by down-regulating β-cateninPharmacol. Res.123,130-142(2017)
Kai, S., Lu, J.-H., Hui, P.-P., et al.Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agentBiochem. Biophys. Res. Commun.452(3),768-774(2014)
