Boldine
Cat. No.：YN483467
CAS No. ：476-70-0
| 产品名称: | Boldine |
| CAS No.: | 476-70-0 |
| Chemical Name: | 5,6,6aS,7-tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol |
| Synonyms: | 波尔定 |
| 分子量: | 327.37 |
| 分子式: | C₁₉H₂₁NO₄ |
| SMILES: | OC1=C(OC)C2=C3C(CCN(C)[C@@]3([H])CC4=CC(O)=C(OC)C=C24)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Boldine 是一种从山苍子 (Litsea cubeba) 根中提取的阿扑吗啡异喹啉生物碱，具有抗氧化，抗炎和细胞保护作用。Boldine 抑制破骨细胞生成，通过下调OPG/RANKL/RANK信号途径来改善骨破坏，并且可用于类风湿性关节炎研究。 |
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Bannach, R., Valenzuela, A., Cassels, B.K., et al.Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytesCell Biol. Toxicol.12(2),89-100(1996)
Santanam, N., Penumetcha, M., Speisky, H., et al.A novel alkaloid antioxidant, Boldine and synthetic antioxidant, reduced form of RU486, inhibit the oxidation of LDL in-vitro and atherosclerosis in vivo in LDLR(-/-) miceAtherosclerosis173(2),203-210(2004)
Backhouse, N., Delporte, C., Givernau, M., et al.Anti-inflammatory and antipyretic effects of boldineAgents Actions42(3-4),114-117(1994)
Moezi, L., Yahosseini, S., Jamshizadeh, A., et al.Acute boldine treatment induces anti-convulsant effects in mice through its antioxidant activityDrug Res. (Stuttg.)69(4),227-233(2019)
